Enroll Course: https://www.coursera.org/learn/shengwu-huaxue
Biochemistry is a cornerstone of modern life sciences, delving into the intricate world of biomolecules at a molecular level. Coursera’s “Structural Biochemistry” course, taught by Professor Rongwu Yang from Nanjing University, offers a comprehensive and engaging introduction to this vital field. As the first part of a planned series, this course lays a robust foundation for understanding metabolism and molecular biology.
Professor Yang, with over two decades of teaching experience, brings a unique passion and clarity to the subject. He emphasizes the practical relevance of biochemistry, highlighting how it empowers individuals to make informed decisions about health, nutrition, and medicine, effectively making students “half a doctor.” The course tackles fundamental questions like why Eskimos have lower rates of cardiovascular disease or how camels survive long periods without water, making the learning process both informative and fascinating.
The syllabus is meticulously structured, covering essential topics in depth:
* **Chapter 1: Structure and Function of Proteins:** This section covers amino acids, peptide bonds, protein structures (primary, secondary, tertiary, quaternary), protein folding, and the relationship between structure and function. It also delves into methods for determining protein structures.
* **Chapter 2: Structure and Function of Nucleic Acids:** Here, students learn about the chemical structures of bases, nucleotides, and the differences between DNA and RNA. The double helix structure of DNA, various RNA types, and the “RNA world” hypothesis are explored.
* **Chapter 3: Properties of Proteins and Nucleic Acids:** This chapter focuses on the physical and chemical properties of biomolecules, including their behavior under different conditions (e.g., denaturation, precipitation) and methods for separation and purification.
* **Chapter 4: Structure and Function of Enzymes:** A deep dive into enzymes, their catalytic mechanisms, factors affecting enzyme activity, enzyme kinetics (including Michaelis-Menten equation), and enzyme regulation.
* **Chapter 5: Structure and Function of Carbohydrates and Lipids:** This unit explores the classification, structures, and functions of sugars and lipids, including monosaccharides, polysaccharides, phospholipids, and the structure of cell membranes.
* **Chapter 6: Structure and Function of Hormones:** The course concludes with an overview of hormones, their classification, mechanisms of action (intracellular and cell surface receptors), and signal transduction pathways, including the roles of second messengers and various enzyme systems.
Professor Yang’s teaching philosophy is encapsulated in the adage, “I hear, I forget; I see, I remember; I do, I understand.” He encourages students to print PPTs, take notes, consult recommended textbooks (like his own “Principles of Biochemistry”), and most importantly, to engage actively with the material. The course is designed for those with a background in general biology and organic chemistry.
Overall, “Structural Biochemistry” is an exceptional course for anyone seeking a solid understanding of the molecular underpinnings of life. Professor Yang’s engaging delivery, coupled with the comprehensive syllabus, makes this an invaluable learning experience. I highly recommend it to students and professionals in biology, medicine, and related fields.
Enroll Course: https://www.coursera.org/learn/shengwu-huaxue