Enroll Course: https://www.coursera.org/learn/toxicology-21
The landscape of toxicology is undergoing a significant transformation, moving away from traditional animal testing towards more innovative, human-relevant approaches. Coursera’s “Toxicology 21: Scientific Applications” course offers a comprehensive exploration of this paradigm shift, aligning with the groundbreaking “Toxicity Testing in the 21st Century: A Vision and a Strategy” report.
This course is an invaluable resource for anyone interested in the future of toxicity testing. It meticulously details the evolution from animal-based studies to high-content, high-throughput integrative testing strategies. Throughout the modules, real-world applications from leading organizations like the EPA and NIH are showcased, demonstrating the dynamic nature of this evolving field.
The syllabus is thoughtfully structured, beginning with a foundational overview of the “Toxicology 21st Century” (Tox21c) field and its core principles. Module 2 delves into practical applications, highlighting how technologies like ToxCast and Tox21 are revolutionizing regulatory processes, using the EPA’s Endocrine Disruptor Screening Program as a prime example of how in vivo testing is being replaced by faster, more efficient methods. The development of in silico models is also a key focus here.
Moving forward, the course introduces the Human Toxome Project in Module 3, exploring advanced ‘omics’ technologies and crucial concepts like Adverse Outcome Pathways (AOPs) and Pathways of Toxicity (PoTs). Module 4 tackles the practicalities of regulatory risk assessment with lessons on ‘read-across’ for REACH compliance and the sophisticated world of organotypic cultures, including cutting-edge organ-on-a-chip and human-on-a-chip models.
Further modules explore the intricate roles of miRNA and epigenetics in environmental health (Module 5), and the critical aspects of in vitro toxicology, such as in vitro to in vivo extrapolation (IVIVE) and physiologically based biokinetic modeling (Module 6). This latter module also touches upon biometry and methods for analyzing big data, essential skills in modern toxicology.
Finally, Module 7 ties everything together by discussing integrated testing strategies and offering a glimpse into the future, beyond just chemical testing, emphasizing the ongoing quest for alternatives to animal testing.
Overall, “Toxicology 21: Scientific Applications” is a highly recommended course for students, researchers, and professionals in toxicology, environmental science, pharmacology, and regulatory affairs. It provides a robust understanding of the latest scientific advancements and their practical implications, equipping learners with knowledge crucial for shaping the future of safety assessment.
Enroll Course: https://www.coursera.org/learn/toxicology-21